EDUCATIONAL RESILIENCE AND THE RISK OF MENTAL DISORDERS

Educational resilience is a complex subject, insufficiently addressed. The concept of educational resilience refers to the student's ability to overcome stressful events in an optimal way. We often observe how students with very good academic results end up developing depressive or anxious states as a result of a stressful event or as a result of a situation with a high degree of difficulty. Our study aims to highlight the following aspects: the frequency of difficult situations faced by first year students from the University of Medicine and Pharmacy of Craiova and the University of Craiova, the degree of resilience approached in terms of time needed to overcome a stressful event, students' ability to recover, the level of stress perceived by students during the exam session, the possibility of the idea of interrupting studies, the degree of motivation for the chosen field of study, the availability of students to participate to a course of emotion management in stressful periods. The study was conducted using a questionnaire covering 15 questions with a simple complement on a sample of 89 students. We believe that the results obtained from this study will contribute significantly to the awareness of the importance of the phenomenon of educational resilience. The causes that often lead to academic failure or dropping out of school are directly proportional to the student's degree of resilience

Clinical Psychological Aspects within The Concept of Pediatric Dentistry

In this paper we aim to describe the pediatric dentistry (pedodontics) wich is a branch of dental medicine dealing exclusively with children and adolescents, being a field that has experienced an impressive development over the past years in our country, being introduced as a specialty in the program of residency in 2016. The purpose of this article is to highlight a number of clinical and psychological aspects resulting from a study of a sample of 10 children on the behavior adopted in the dental office in two distinct situation

Evaluation of phenolic compounds in white wines treated with enzymes

Wine's quality is influenced both by the grape characteristics and winemaking protocols. Awareness of the significant role of enzymes preparations in beverages technologies contributes to the optimization of the manufacturing process, for improving the chemical composition of the resulting wine and its organoleptic properties. This paper focuses on monitoring the impact of different commercial enzymes (pectinases and β-glycosides) on the main phenolic compounds content of Sauvignon blanc wines. For this experiment, ten phenolic compounds were quantified using a liquid-chromatography (LC) system coupled with ion trap mass spectrometer. The results indicated a significant influence of enzymes on wine’s phenolic fraction. Experimental samples presented high content in protocatechuic acid (9.99 - 13.75 μg/mL) and caftaric acid (2.69 - 9.80 μg/mL). The use of pectinases lead to an increase of phenolic compound’s concentration compared to the control

Functional Implications of Oral Papillomatosis

The papillomatous lesion has a number of implications that destabilize the normal functioning of the stomatognathic system, but also it has psychological implications. A patient with a papilloma located in an area of maximum visibility tends to be less exposed in public, to reduce socialization, to feel embarrassed. Oral papilloma affects the masticatory function, phonation, but also aesthetics.Understanding how local immunity works in patients diagnosed with oral papilloma is essential. Local immunity influences the evolution of the papillomatous oral lesion. Toll-like receptors are extremely important in the immune process of oral papilloma. Toll-like receptors can be used as indicators of lesion progression. A reduced expression of these receptors in the focus of the lesion is suggestive of pathological progress. It is also emphasized that in the oral cavity we find a well-represented local immune system which cells have an immune role and whose expression influences the evolution of the disease. The most incriminating factor in the occurrence of oral papilloma is HPV infection. The persistent inflammatory process produced by the HPV virus stimulates the development of oral, pharyngeal, laryngeal neoplasms. The HPV virus acts as a direct inducer in the process of transforming the benign lesion into a malignant lesion. Macrophages play an important role in the malignancy potential induced by the HPV virus. Macrophages are activated by increasing the metabolic rate and fighting tumor cells.</p

Nesfatin-1 activates cardiac vagal neurons of nucleus ambiguus and elicits bradycardia in conscious rats.

Nesfatin-1, a peptide whose receptor is yet to be identified, has been involved in the modulation of feeding, stress, and metabolic responses. More recently, increasing evidence supports a modulatory role for nesfatin-1 in autonomic and cardiovascular activity. This study was undertaken to test if the expression of nesfatin-1 in the nucleus ambiguus, a key site for parasympathetic cardiac control, may be correlated with a functional role. As we have previously demonstrated that nesfatin-1 elicits Ca²⁺ signaling in hypothalamic neurons, we first assessed the effect of this peptide on cytosolic Ca²⁺ in cardiac pre-ganglionic neurons of nucleus ambiguus. We provide evidence that nesfatin-1 increases cytosolic Ca²⁺ concentration via a Gi/o-coupled mechanism. The nesfatin-1-induced Ca²⁺ rise is critically dependent on Ca²⁺ influx via P/Q-type voltage-activated Ca²⁺ channels. Repeated administration of nesfatin-1 leads to tachyphylaxis. Furthermore, nesfatin-1 produces a dose-dependent depolarization of cardiac vagal neurons via a Gi/o-coupled mechanism. In vivo studies, using telemetric and tail-cuff monitoring of heart rate and blood pressure, indicate that microinjection of nesfatin-1 into the nucleus ambiguus produces bradycardia not accompanied by a change in blood pressure in conscious rats. Taken together, our results identify for the first time that nesfatin-1 decreases heart rate by activating cardiac vagal neurons of nucleus ambiguus. Our results indicate that nesfatin-1, one of the most potent feeding peptides, increases cytosolic Ca²⁺ by promoting Ca²⁺ influx via P/Q channels and depolarizes nucleus ambiguus neurons; both effects are Gi/o-mediated. In vivo studies indicate that microinjection of nesfatin-1 into nucleus ambiguus produces bradycardia in conscious rats. This is the first report that nesfatin-1 increases the parasympathetic cardiac tone

Innate Immune Response as a New Challenge in Periodontal Inflammation

Gingivitis and periodontitis are induced by numerous pathogenic microbiota hosted in the subgingival biofilm that first trigger the innate immune response. Innate immune response is part of a homeostatic system which is the first line defence and defines the host inherited resistance to infection. Both genetic and environmental factors are involved in variable individual susceptibility to inflammation of periodontal tissues. That is why, although more than 600 bacterial species have been detected in the periodontal plaque, the type of bacteria incriminated in the development of the inflammation is still unclear. Moreover, in the last decade gene polymorphisms have been largely recognised as important conditions associated with increased susceptibility to periodontal diseases. Manipulating the immune response by the development of drugs that inhibit adverse host reactions and promote beneficial effects might be of therapeutic or prophylactic importance. This work intends to assess the importance of Toll-like receptors as main effectors of the innate immune response in the triggering, maintenance and progression of periodontal inflammation, as well as of the involvement of synthetic molecules targeting TLR signalling pathways in treating periodontal diseases

Cardiopatia ischemică – aspecte noi de diagnostic şi tratament intervenţional. Caz clinic

Bolile aparatului circulator au fost cauza decesului a 657,4 persoane la 100000 locuitori, dintre care cardiopatia ischemică deține circa 60%. În RM în a. 2006 incidența CPI a fost estimată de 142,5 la 10000 locuitori și mortalitate în a. 2008 - 1175,0 persoane la 100000 locuitori. Coronaroangiografia și angioplastia percutană sunt metode moderne de tratament a bolii cardiace coronariene, caracterizate prin invazivitate scăzută și eficiență ridicată. Raportăm cazul clinic a unui bărbat de 50 de ani cu diagnosticul: Cardiopatie ischemică, căruia i s-a efectuat coronaroangiografia, iar ca metodă de tratament revascularizare prin PCI